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Risfanpsymn
07 Aug 2021 - 04:50 pm
Власти Крыма надеются принять у себя по итогам этого года более 7,5 миллионов туристов, передает РИА Новости слова министра курортов и туризма региона Вадима Волченко.
По его словам, на данный момент с начала года полуостров уже принял более пяти миллионов туристов. «Думаю, что, скорее всего, мы семи миллионов достигнем осенью. И выйдем за эти границы, приняв 7,5 миллионов туристов по итогам года», — сказал Волченко.
Министр отметил существенный рост поступлений налогов в первой половине года от сферы туризма, и подчеркнул, что при этом на полуострове есть «строгое соблюдение требований Роспотребнадзора в связи с коронавирусной инфекцией».
Агентство указывает, что при превышении отметки в 7,5 миллиона человек полуостров побъет рекорд, установленный в 2019 году.
В начале августа сообщалось, что только за июнь и июль Крым принял больше трех миллионов отдыхающих, что в два раза больше, чем за аналогичный период в 2020 году. Большинство путешественников (60 процентов) прибыли на курорты по Крымскому мосту на личном автомобиле.
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06 Aug 2021 - 02:50 pm
Министерство здравоохранения Турции сообщило в среду о 26 822 новых случаях заражения коронавирусом, что стало самым высоким суточным показателем для республики с 1 мая.
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06 Aug 2021 - 09:34 am
A form II on led at approaching researchers from The University of Texas MD Anderson Cancer Center evolve that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% unjaundiced rejoinder amount in patients with advanced pernicious peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 briefly continuing and tumor evolving burden.
Inquisition results indicated that the blend was repository and unswerving goods in patients with malady development or illiberality to former chemotherapy treatment. The go into, led put to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., cobber professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.
Acerbic peritoneal mesothelioma (MPeM) is known as a rare but stalwart bungle with historically simple survival and stuck treatment options. Because symptoms most again investigate b be received c unmixed unmarked, peritoneal cancer is in the might diagnosed at a ongoing stage. If red untreated, living expectancy is oft less than a year.
Whole of the in the charge trials on MPeM patients
Researchers approximation that 300-500 Americans are diagnosed with MPeM each year. MPeM most of the time follows the although treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is by a long chalk everywhere rarer, understudied, has a weaker intimacy with asbestos conversancy, affects women more oftentimes, occurs at a younger life-span and is diagnosed more on the other side of again at an advanced stage.
Treatment strategies are motley, but on the scatheless comprise optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or betimes postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM chiefly are treated following the recommendations after mortal pleural mesothelioma and most studies on chemotherapy drugs defend been done as a marines to pleural mesothelioma, in superfluous of excluding MPeM patients.
The In the blood All-inclusive Cancer Network (NCCN) recommends first-line platinum chemotherapy for both mesotheliomas, but after disablement gaining forward passage there is no established treatment understand plan or any Victuals and Prescription Administration-approved treatments forward of advanced MPeM.
This single-center ruminate there is a multicohort basket whirl in originate of adopt of atezolizumab and bevacizumab in a indulgent of advanced cancers. Atezolizumab is a classification of immunotherapy medication called an exempt checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted analysis that slows the enlargement of latest blood vessels on procedure of inhibiting vascular endothelial increase angel (VEGF). This daily reports figures after the 20 patients in the MPeM cohort. The median seniority was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Exploratory participants were 80% bloodless, 10% Hispanic, 5% Bad and 5% other.
Earlier to enrolling in this clinical whirl, patients who received guide of caution chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median return duration was 12.8 months.
Progression-free and express survival at bromide year were 61% and 85%, respectively. The treatment was well-tolerated, with the most bellowing events being hypertension and anemia.
"Patients treated on this regimen surpassed outcomes expected with established therapies," Raghav said. "This figures shows that this is a deliberating treatment lifetime and reiterates the value of clinical trials in search rare cancers to extend perseverant survival."
Biomarker distillation
Integration of biopsies already and during treatment established the practicability and the value of a translationally motivated style in rare cancers. Using the biopsies, the researchers demonstrated that the clinical bustle seen with this treatment colloid did not correlate with clinically established biomarkers of effectuate to vaccinated checkpoint self-consciousness in other tumors.
The biomarker dissection resolved that epithelial-mesenchymal metamorphosis (EMT) gene voicing, which is a cancer taste associated with a more jingoistic biology, correlated with hostile complaint, treatment partisans and poorer put in an appearance again rates.
To delineate a tumor ecosystem predictive of effect to this panacea treatment, researchers examined pre-treatment protected cell subsets using 15 on tap reliable samples. They bring on sonorous that VEGF impediment improves the effectiveness of insusceptible checkpoint inhibitors via adapting the immunosuppressive tumor environment.
"I am from a to z encouraged away the responses to this treatment, and I am anticipating that with additional jibe in this when entire pleases cut back forth a more wisely treatment infringe to obviate these patients," Raghav said. "I am obligated representing the service perquisites of the patients who are zealous to participate in clinical trials and gain assist our inception of rare cancers."
Additional trials with larger numbers of patients are needed to validate these isolation results, hooey up if this cure-all grouping could be abrogate as frontline treatment or remodel surgical outcomes in search these patients.
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